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NEWS: [26-06-2009] - Michael Jackson, pop music legend, dead at 50

Source: 
CNN.com - http://edition.cnn.com/2009/SHOWBIZ/Music/06/25/jackson/index.html?eref=rss_topstories

Michael Jackson, the show-stopping singer whose best-selling albums -- including "Off the Wall," "Thriller" and "Bad" -- and electrifying stage presence made him one of the most popular artists of all time, died Thursday, CNN has confirmed.

He was 50.

He collapsed at his residence in the Holmby Hills section of Los Angeles, California, about noon Pacific time, suffering cardiac arrest, according to brother Randy Jackson. He died at UCLA Medical Center.

Lt. Fred Corral of the Los Angeles County Coroner's Office said an autopsy would probably be done on the singer Friday, with results expected that afternoon.

"Michael Jackson made culture accept a person of color," the Rev. Al Sharpton said. "To say an 'icon' would only give these young people in Harlem a fraction of what he was. He was a historic figure that people will measure music and the industry by."

Jackson's blazing rise to stardom -- and later fall from grace -- is among the most startling of show business tales. The son of a steelworker, he rose to fame as the lead singer of the Jackson 5, a band he formed with his brothers in the late 1960s. By the late '70s, as a solo artist, he was topping the charts with cuts from "Off the Wall," including "Rock With You" and "Don't Stop 'Til You Get Enough."

In 1982, he released "Thriller," an album that eventually produced seven hit singles. An appearance the next year on a Motown Records 25th-anniversary special cemented his status as the biggest star in the country.
For the rest of the 1980s, they came no bigger. "Thriller's" follow-up, 1987's "Bad," sold almost as many copies. A new Jackson album -- a new Jackson appearance -- was a pop culture event.

The pop music landscape was changing, however, opening up for rap, hip-hop and what came to be called "alternative" -- and Jackson was seen as out of step.

Random Topic Review

Is it possible that a deficiency of a coagulation factor result in Thrombosis??

Y.Abbas's picture

An interesting thing that I've learned during the blood & lymph module is that a deficiency in coagulation factor XII can lead to thrombosis!!??
How can this be possible?!
What we all know is that any deficiency in any coagulation factor result in bleeding, such as in the case of heamophilia which results from deficiency of either factor VIII or XI.
Dr. Salah Al-Humood mentioned during one of the wrap-ups that deficiency of coagulation factor XII leads to thrombosis, but he didn't say how. His words stayed in my mind, and I looked for an explanation. By connecting the whole week together, I found what I was looking for.
There are 2 models of coagulation. In the old model, the coagulation starts by activation of factor XII , while in the new model, there is no role for factor XII in producing a clot. Both models share the fact that factor XII produce bradykinin, which is a vasodilator and a stimulant of tPA (tissue plasminogen activator). Now lets look at the role of both vasodilation and tPA in hemostasis:
1) After an injury, vasoconstriction takes place. This will minimize the vessel diameter and slow bleeding. So vasodilation will increase the bleeding.
2) tPA binds to plasminogen within the clot, converting it into plasmin. Plasmin has an important role in fibrinolysis.
So we can see that bradykinin is used to dissolve the clot, and it is produced by coagulation factor XII. A deficiency of this factor will lead to low bradykinin levels --> less vasodilation, and low tPA levels --> more slow bleeding, and less activation of plasminogen (less fibrinolysis) --> THROMBOSIS..
[EDITED BY DR.BISHO]

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